Q-Der: new neuroprotective evidence in Parkinson's disease models

Q-Der, the third-generation Coenzyme Q10 analog developed in Prof. Giovanni Zappia's laboratory, has shown significant results in protecting nerve cells in preclinical models of Parkinson's disease.

The study, conducted on SH-SY5Y cell lines and on the Caenorhabditis elegans animal model, documents a 40% reduction in oxidative stress compared to standard CoQ10, with a 38% improvement in mitochondrial respiratory chain efficiency.

The mechanism of action is based on Q-Der's ability to more effectively penetrate the inner mitochondrial membrane. The results, published in Frontiers in Molecular Biosciences (2025), open concrete prospects for the development of neuroprotective formulations.

The compound is available on request for research use. For information on quantities and supply conditions, please contact the laboratory.